Leonard reinstates Anything Can Happen Thursday, and it leads the regimented Sheldon to attempt something spontaneous, which creates friction among Penny, Amy and Bernadette. Raj requests help from Howard in prepping for a date with Emily.
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Sheldon receives counseling from his childhood TV idol, Professor Proton, while Penny and Leonard reach a relationship milestone and turn it into a competition and Bernadette and Amy turn Star Wars Day into a special event for the guys.
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A trying day at the movie shoot leaves Penny with questions about her life choices, so she decides to act on it; and caring for a bedridden Mrs. Wolowitz proves a challenge for Howard and Bernadette.
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Amy and Leonard take a surprise road trip to Arizona, while Penny goes on a job interview at Bernadette's company, and Howard has problems wrapping his head around Stuart's relationship with Mrs. Wolowitz.
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Sheldon is ordered to teach a class, and the gang is surprised when Howard signs up to take it; and tensions between Penny and Bernadette afford Amy an opportunity to play one against the other.
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A nervous Wolowitz is thrown for a loop when NASA asks him to toss out the first pitch at a Los Angeles Angels baseball game. Meanwhile, Sheldon brags that he and Amy are a better couple than Leonard and Penny.
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Raj's girlfriend, Emily, gives Penny the cold shoulder after he reveals some info about their past history; and the guys contemplate buying into Stuart's comic-book emporium.
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Amy and Bernadette accuse former party girl Penny of becoming a party pooper when she lets an email from work impact their girls' weekend in Las Vegas. Meanwhile, the guys brainstorm about inventing something cool.
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Sheldon and Raj undertake an underground research expedition that turns into a test of how long before they get under each other's skin. Meanwhile, Leonard and Penny argue about money.
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Penny's flirtatious sales pitch leaves a doctor-client smitten and the guys must pitch in to help her deal with him, while, Bernadette and Amy debate whether female scientists ought to play the sexuality card.
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Amy and Bernadette organize a prom to be held atop the guys' apartment complex but Sheldon is leery of all the prom pomp, circumstance and romancing that goes with it.
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Leonard needs surgery for a deviated septum, and Sheldon gets his nose out of joint because he feels an operation is too dangerous and that his roommate may not make it out alive.
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It's a banner day for Sheldon as he bids a sad farewell to his Fun With Flags podcast. Meanwhile, Leonard, Howard and Raj probe a late professor's research in search of some hidden significance.
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