Amy and Leonard take a surprise road trip to Arizona, while Penny goes on a job interview at Bernadette's company, and Howard has problems wrapping his head around Stuart's relationship with Mrs. Wolowitz.
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Sheldon is ordered to teach a class, and the gang is surprised when Howard signs up to take it; and tensions between Penny and Bernadette afford Amy an opportunity to play one against the other.
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Raj's girlfriend, Emily, gives Penny the cold shoulder after he reveals some info about their past history; and the guys contemplate buying into Stuart's comic-book emporium.
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Amy and Bernadette accuse former party girl Penny of becoming a party pooper when she lets an email from work impact their girls' weekend in Las Vegas. Meanwhile, the guys brainstorm about inventing something cool.
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Sheldon and Raj undertake an underground research expedition that turns into a test of how long before they get under each other's skin. Meanwhile, Leonard and Penny argue about money.
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Amy and Bernadette organize a prom to be held atop the guys' apartment complex but Sheldon is leery of all the prom pomp, circumstance and romancing that goes with it.
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Penny's flirtatious sales pitch leaves a doctor-client smitten and the guys must pitch in to help her deal with him, while, Bernadette and Amy debate whether female scientists ought to play the sexuality card.
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Leonard needs surgery for a deviated septum, and Sheldon gets his nose out of joint because he feels an operation is too dangerous and that his roommate may not make it out alive.
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Sheldon becomes concerned that his cushy lifestyle is impacting his professional progress and keeping him from achieving scientific renown, so he asks the gang to make life more difficult for him.
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ABOUT
Leonard and Sheldon are brilliant physicists, the kind of ''beautiful minds'' that understand how the universe works. But none of that genius helps them interact with people, especially women. All this begins to change when a free-spirited beauty named Penny moves in next door.
